Piperaquine-d6

Modify Date: 2024-01-02 12:02:53

Piperaquine-d6 Structure
Piperaquine-d6 structure
Common Name Piperaquine-d6
CAS Number 1261394-71-1 Molecular Weight 541.548
Density 1.3±0.1 g/cm3 Boiling Point 721.1±60.0 °C at 760 mmHg
Molecular Formula C29H26D6Cl2N6 Melting Point N/A
MSDS N/A Flash Point 389.9±32.9 °C

 Use of Piperaquine-d6


Piperaquine-d6 is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].

 Names

Name 4,4'-[(2H6)-1,3-Propanediyldi-4,1-piperazinediyl]bis(7-chloroquinoline)
Synonym More Synonyms

 Piperaquine-d6 Biological Activity

Description Piperaquine-d6 is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11.  

[3]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 721.1±60.0 °C at 760 mmHg
Molecular Formula C29H26D6Cl2N6
Molecular Weight 541.548
Flash Point 389.9±32.9 °C
Exact Mass 540.244202
LogP 5.15
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.664

 Synonyms

4,4'-[(2H6)-1,3-Propanediyldi-4,1-piperazinediyl]bis(7-chloroquinoline)
Quinoline, 4,4'-(1,3-propanediyl-d6di-4,1-piperazinediyl)bis[7-chloro-