Piperaquine-d6

Names

[ CAS No. ]:
1261394-71-1

[ Name ]:
Piperaquine-d6

[Synonym ]:
4,4'-[(2H6)-1,3-Propanediyldi-4,1-piperazinediyl]bis(7-chloroquinoline)
Quinoline, 4,4'-(1,3-propanediyl-d6di-4,1-piperazinediyl)bis[7-chloro-

Biological Activity

[Description]:

Piperaquine-d6 is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11.  

[3]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
721.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H26D6Cl2N6

[ Molecular Weight ]:
541.548

[ Flash Point ]:
389.9±32.9 °C

[ Exact Mass ]:
540.244202

[ LogP ]:
5.15

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.664

Related Compounds