JCP174

Modify Date: 2025-08-26 00:31:25

JCP174 structure	Common Name	JCP174
	CAS Number	126062-19-9	Molecular Weight	253.682
	Density	1.4±0.1 g/cm3	Boiling Point	463.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₂ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	234.1±28.7 °C

Use of JCP174

JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].

Name	7-Amino-4-chloro-3-propoxy-isocoumarin
Synonym	More Synonyms

Description	JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase
References	[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6. [2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18. [3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

References

[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6.

[2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18.

[3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.

Density	1.4±0.1 g/cm3
Boiling Point	463.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₂ClNO₃
Molecular Weight	253.682
Flash Point	234.1±28.7 °C
Exact Mass	253.050568
LogP	2.10
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.601

7-Amino-4-chloro-3-propoxy-isocoumarin

MFCD22378306

1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-propoxy-

7-Amino-4-chloro-3-propoxy-1H-isochromen-1-one

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JCP174

Use of JCP174

Names

JCP174 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.