126062-19-9

126062-19-9 structure

Name: JCP174
Chemical Name: 7-Amino-4-chloro-3-propoxy-isocoumarin
CAS Number: 126062-19-9
Molecular Formula: C₁₂H₁₂ClNO₃
Molecular Weight: 253.682
Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
Create Date: 2018-06-26 01:20:07
Modify Date: 2025-08-26 00:31:25
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].

Name	7-Amino-4-chloro-3-propoxy-isocoumarin
Synonyms	7-Amino-4-chloro-3-propoxy-isocoumarin MFCD22378306 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-propoxy- 7-Amino-4-chloro-3-propoxy-1H-isochromen-1-one

Description	JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase
References	[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6. [2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18. [3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.