T3D-959
Modify Date: 2025-08-25 18:22:40
T3D-959 structure
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Common Name | T3D-959 | ||
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| CAS Number | 1258076-66-2 | Molecular Weight | 443.467 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26NNaO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of T3D-959T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively; prevents STZ-induced neurotoxicity, and shows clear therapeutic and neuroprotective effects in an established model of sporadic AD. Alzheimer Disease Phase 2 Clinical |
| Name | Sodium [(1S)-5-{2-[5-ethyl-2-(4-methoxyphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl]acetate |
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| Synonym | More Synonyms |
| Description | T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively; prevents STZ-induced neurotoxicity, and shows clear therapeutic and neuroprotective effects in an established model of sporadic AD. Alzheimer Disease Phase 2 Clinical |
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| References | References 1. Tong M, et al. J Alzheimers Dis. 2016;51(1):123-38. 2. Tong M, et al. J Alzheimers Dis Parkinsonism. 2016 Jun;6(3). pii: 238. View Related Products by Target PPAR Alzheimer Disease |
| Molecular Formula | C25H26NNaO5 |
|---|---|
| Molecular Weight | 443.467 |
| Exact Mass | 443.170868 |
| InChIKey | ICCAFCVDQOALPN-FERBBOLQSA-M |
| SMILES | CCc1oc(-c2ccc(OC)cc2)nc1CCOc1ccc2c(c1)CCC2CC(=O)[O-].[Na+] |
| Sodium [(1S)-5-{2-[5-ethyl-2-(4-methoxyphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl]acetate |
| 1H-Indene-1-acetic acid, 5-[2-[5-ethyl-2-(4-methoxyphenyl)-4-oxazolyl]ethoxy]-2,3-dihydro-, sodium salt, (1S)- (1:1) |