T3D-959

Names

[ Name ]:
T3D-959

[Synonym ]:
Sodium [(1S)-5-{2-[5-ethyl-2-(4-methoxyphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl]acetate
1H-Indene-1-acetic acid, 5-[2-[5-ethyl-2-(4-methoxyphenyl)-4-oxazolyl]ethoxy]-2,3-dihydro-, sodium salt, (1S)- (1:1)

Biological Activity

[Description]:

T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively; prevents STZ-induced neurotoxicity, and shows clear therapeutic and neuroprotective effects in an established model of sporadic AD. Alzheimer Disease Phase 2 Clinical

[References]

References 1. Tong M, et al. J Alzheimers Dis. 2016;51(1):123-38. 2. Tong M, et al. J Alzheimers Dis Parkinsonism. 2016 Jun;6(3). pii: 238. View Related Products by Target PPAR Alzheimer Disease

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₆NNaO₅

[ Molecular Weight ]:
443.467

[ Exact Mass ]:
443.170868

Related Compounds

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