GSK2236805

Modify Date: 2024-01-02 19:03:36

GSK2236805 Structure
GSK2236805 structure
Common Name GSK2236805
CAS Number 1256390-53-0 Molecular Weight 796.91
Density 1.4±0.1 g/cm3 Boiling Point 1115.3±65.0 °C at 760 mmHg
Molecular Formula C42H52N8O8 Melting Point N/A
MSDS N/A Flash Point 628.3±34.3 °C

 Use of GSK2236805


GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively[1].

 Names

Name GSK-2336805
Synonym More Synonyms

 GSK2236805 Biological Activity

Description GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively[1].
Related Catalog
Target

pEC50: 10.4 (gt1a); 11.1 µM (gt1b)[1]

References

[1]. Kazmierski WM, et al. Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound. J Med Chem. 2014 Mar 13;57(5):2058-73.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1115.3±65.0 °C at 760 mmHg
Molecular Formula C42H52N8O8
Molecular Weight 796.91
Flash Point 628.3±34.3 °C
Exact Mass 796.390808
LogP 5.44
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.644

 Synonyms

Carbamic acid, N-[(1S)-1-[[(2S)-2-[5-[4'-[2-[(8S)-7-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-1,4-dioxa-7-azaspiro[4.4]non-8-yl]-1H-imidazol-5-yl][1,1'-biphenyl]-4-yl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-, methyl ester
MFCD28963895
Methyl [(2S)-1-{(8S)-8-[4-(4'-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]non-7-yl}-3-methyl-1-oxo-2-butanyl]carbamate
GSK-2336805
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