GSK2236805

Names

[ Name ]:
GSK2236805

[Synonym ]:
Carbamic acid, N-[(1S)-1-[[(2S)-2-[5-[4'-[2-[(8S)-7-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-1,4-dioxa-7-azaspiro[4.4]non-8-yl]-1H-imidazol-5-yl][1,1'-biphenyl]-4-yl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-, methyl ester
MFCD28963895
Methyl [(2S)-1-{(8S)-8-[4-(4'-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]non-7-yl}-3-methyl-1-oxo-2-butanyl]carbamate
GSK-2336805

Biological Activity

[Description]:

GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

[Target]

pEC50: 10.4 (gt1a); 11.1 µM (gt1b)[1]

[References]

[1]. Kazmierski WM, et al. Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound. J Med Chem. 2014 Mar 13;57(5):2058-73.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1115.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₅₂N₈O₈

[ Molecular Weight ]:
796.91

[ Flash Point ]:
628.3±34.3 °C

[ Exact Mass ]:
796.390808

[ LogP ]:
5.44

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.644

Related Compounds

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