JTE-952
Modify Date: 2024-01-10 15:05:45
JTE-952 structure
|
Common Name | JTE-952 | ||
|---|---|---|---|---|
| CAS Number | 1255303-54-8 | Molecular Weight | 518.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H34N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JTE-952JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1]. |
| Name | JTE-952 |
|---|
| Description | JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 13 nM (CSF1R), 261 nM (TrkA)[1]. |
| In Vivo | JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1]. Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1]. Dosage: 3 mg/kg. Administration: Oral once-daily. Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion. |
| References |
| Molecular Formula | C30H34N2O6 |
|---|---|
| Molecular Weight | 518.60 |