1255303-54-8

1255303-54-8 structure

Name: JTE-952
Chemical Name: JTE-952
CAS Number: 1255303-54-8
Molecular Formula: C₃₀H₃₄N₂O₆
Molecular Weight: 518.60
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2019-06-05 11:24:34
Modify Date: 2024-01-10 15:05:45
JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].

Name	JTE-952

Description	JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
Target	IC50: 13 nM (CSF1R), 261 nM (TrkA)[1].
In Vivo	JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1]. Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1]. Dosage: 3 mg/kg. Administration: Oral once-daily. Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion.
References	[1]. Ikegashira K, et al. Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.

Molecular Formula	C₃₀H₃₄N₂O₆
Molecular Weight	518.60