Compound 7

Modify Date: 2025-08-27 16:52:56

Compound 7 Structure
Compound 7 structure
Common Name Compound 7
CAS Number 1252003-13-6 Molecular Weight 335.40
Density N/A Boiling Point N/A
Molecular Formula C20H21N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Compound 7


HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].

 Names

Name HDAC-IN-4

 Compound 7 Biological Activity

Description HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].
Related Catalog
Target

pIC50: 7.2 (HDAC6), and 6.8 (HDAC10)[1]

In Vitro HDAC-IN-4 inhibits HDAC1, HDAC2, HDAC3, HDAC8 and HDAC10 with pIC50s of 5.5, 4.6, 5.4, 5.4, 6.7 in FRET assay, respectively[1]. HDAC-IN-4 is more potent against HDAC6 than Tubastatin A, suggests that HDAC-IN-4 may be a better HDAC6 probe than Tubastatin A[1].
References

[1]. Géraldy M, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443.

 Chemical & Physical Properties

Molecular Formula C20H21N3O2
Molecular Weight 335.40
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