Navamepent

Modify Date: 2025-08-21 06:07:04

Navamepent Structure
Navamepent structure
Common Name Navamepent
CAS Number 1251537-11-7 Molecular Weight 174.237
Density 1.0±0.1 g/cm3 Boiling Point 227.4±23.0 °C at 760 mmHg
Molecular Formula C18H24O4 Melting Point N/A
MSDS N/A Flash Point 82.9±15.4 °C

 Use of Navamepent


Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells.

 Names

Name 10241
Synonym More Synonyms

 Navamepent Biological Activity

Description Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells.
Related Catalog
References

[1]. Cholkar K, Gilger BC, Mitra AK. Topical delivery of aqueous micellar resolvin E1 analog (RX-10045) [published correction appears in Int J Pharm. 2016 Jul 25;509(1-2):528]. Int J Pharm. 2016;498(1-2):326-334.

[2]. Torricelli AA, Santhanam A, Agrawal V, Wilson SE. Resolvin E1 analog RX-10045 0.1% reduces corneal stromal haze in rabbits when applied topically after PRK. Mol Vis. 2014;20:1710-1716. Published 2014 Dec 23.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 227.4±23.0 °C at 760 mmHg
Molecular Formula C18H24O4
Molecular Weight 174.237
Flash Point 82.9±15.4 °C
Exact Mass 174.125595
LogP 1.29
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.438
InChIKey ZVOCIIHCJJEFRQ-BHXBHYJPSA-N
SMILES C#CCC(O)C=CC=CC#CC(O)CCCC(=O)OC(C)C

 Synonyms

Q7789B8MWM
10241
Isopropyl (5R)-5-hydroxyhexanoate
Hexanoic acid, 5-hydroxy-, 1-methylethyl ester, (5R)-
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