Navamepent

Names

[ Name ]:
Navamepent

[Synonym ]:
Q7789B8MWM
10241
Isopropyl (5R)-5-hydroxyhexanoate
Hexanoic acid, 5-hydroxy-, 1-methylethyl ester, (5R)-

Biological Activity

[Description]:

Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Cholkar K, Gilger BC, Mitra AK. Topical delivery of aqueous micellar resolvin E1 analog (RX-10045) [published correction appears in Int J Pharm. 2016 Jul 25;509(1-2):528]. Int J Pharm. 2016;498(1-2):326-334.

[2]. Torricelli AA, Santhanam A, Agrawal V, Wilson SE. Resolvin E1 analog RX-10045 0.1% reduces corneal stromal haze in rabbits when applied topically after PRK. Mol Vis. 2014;20:1710-1716. Published 2014 Dec 23.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
227.4±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₄O₄

[ Molecular Weight ]:
174.237

[ Flash Point ]:
82.9±15.4 °C

[ Exact Mass ]:
174.125595

[ LogP ]:
1.29

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.438

Related Compounds

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