VU0364739

Modify Date: 2025-09-24 12:18:39

Use of VU0364739

VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation[1].

Name	N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-ethyl]-2-naphthalenecarboxamide
Synonym	More Synonyms

Description	VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Target	PLD[1]
References	[1]. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.

Molecular Formula	C₂₆H₂₇FN₄O₂
Molecular Weight	446.52
Exact Mass	446.21200
PSA	64.68000
LogP	3.85980
InChIKey	MSTXJJGAXXJCBY-UHFFFAOYSA-N
SMILES	O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1ccc2ccccc2c1

N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5 ]decan-8-yl)ethyl)-2-naphthamide

N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide

N-[2-[1-(3-FLUOROPHENYL)-4-OXO-1,3,8-TRIAZASPIRO[4.5]DEC-8-YL]ETHYL]-2-NAPHTHALENECARBOXAMIDE