1244639-78-8

1244639-78-8 structure

Name: VU0364739
Chemical Name: N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-ethyl]-2-naphthalenecarboxamide
CAS Number: 1244639-78-8
Molecular Formula: C₂₆H₂₇FN₄O₂
Molecular Weight: 446.52
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2018-06-04 10:22:31
Modify Date: 2025-09-24 12:18:39
VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation[1].

Name	N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-ethyl]-2-naphthalenecarboxamide
Synonyms	N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5 ]decan-8-yl)ethyl)-2-naphthamide N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide N-[2-[1-(3-FLUOROPHENYL)-4-OXO-1,3,8-TRIAZASPIRO[4.5]DEC-8-YL]ETHYL]-2-NAPHTHALENECARBOXAMIDE

Description	VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Target	PLD[1]
References	[1]. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.