(R)-DRF053 dihydrochloride
Modify Date: 2024-04-03 10:45:11
(R)-DRF053 dihydrochloride structure
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Common Name | (R)-DRF053 dihydrochloride | ||
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| CAS Number | 1241675-76-2 | Molecular Weight | 490.429 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H29Cl2N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R)-DRF053 dihydrochloride(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively; exhibits antiproliferative activity against human neuroblastoma SH-SY5Y cells with EC50 of 17.2 uM, prevents the CK1-dependent production of amyloid-beta in a cell model; specifically increases the number of duct-derived β-cells without affecting their proliferation. |
| Name | (2R)-2-[(9-Isopropyl-6-{[3-(2-pyridinyl)phenyl]amino}-9H-purin-2-yl)amino]-1-butanol dihydrochloride |
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| Synonym | More Synonyms |
| Description | (R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively; exhibits antiproliferative activity against human neuroblastoma SH-SY5Y cells with EC50 of 17.2 uM, prevents the CK1-dependent production of amyloid-beta in a cell model; specifically increases the number of duct-derived β-cells without affecting their proliferation. |
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| References | References 1. Oumata N, et al. J Med Chem. 2008 Sep 11;51(17):5229-42. 2. Zelenak C, et al. Cell Physiol Biochem. 2012;29(1-2):171-80. 3. Liu KC, et al. Diabetes. 2018 Jan;67(1):58-70. View Related Products by Target Casein Kinase Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C23H29Cl2N7O |
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| Molecular Weight | 490.429 |
| Exact Mass | 489.181061 |
| (2R)-2-[(9-Isopropyl-6-{[3-(2-pyridinyl)phenyl]amino}-9H-purin-2-yl)amino]-1-butanol dihydrochloride |
| (2R)-2-[(9-Isopropyl-6-{[3-(pyridin-2-yl)phenyl]amino}-9H-purin-2-yl)amino]butan-1-ol dihydrochloride |
| 1-Butanol, 2-[[9-(1-methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-, (2R)-, hydrochloride (1:2) |