MK-1421
Modify Date: 2024-04-13 16:36:53
MK-1421 structure
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Common Name | MK-1421 | ||
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| CAS Number | 1235995-16-0 | Molecular Weight | 525.537 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 794.8±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H24FN9O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 434.5±35.7 °C | |
Use of MK-1421A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 2.3 nM, >2,500-fold selectivity over SSTR1/2/4/5 (IC50>5 uM); shows excellent efficacy in a mouse model of glucose excursion (oGTT) and demonstrates glucose-dependent release of insulin from relevant human tissue. |
| Name | 5-{(1R,3R)-1-(1-Ethyl-1H-pyrazol-4-yl)-3-[5-(5-fluoro-2-pyridinyl)-1H-imidazol-2-yl]-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl}-3-methyl-1,3,4-oxadiazol-2(3H)-one |
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| Synonym | More Synonyms |
| Description | A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 2.3 nM, >2,500-fold selectivity over SSTR1/2/4/5 (IC50>5 uM); shows excellent efficacy in a mouse model of glucose excursion (oGTT) and demonstrates glucose-dependent release of insulin from relevant human tissue. |
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| References | References 1. Shah SK, et al. ACS Med Chem Lett. 2015 Mar 18;6(5):513-7. View Related Products by Target Somatostatin Receptor |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 794.8±70.0 °C at 760 mmHg |
| Molecular Formula | C27H24FN9O2 |
| Molecular Weight | 525.537 |
| Flash Point | 434.5±35.7 °C |
| Exact Mass | 525.203674 |
| LogP | 0.37 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.791 |
| 1,3,4-Oxadiazol-2(3H)-one, 5-[(1R,3R)-1-(1-ethyl-1H-pyrazol-4-yl)-3-[5-(5-fluoro-2-pyridinyl)-1H-imidazol-2-yl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]-3-methyl- |
| 5-{(1R,3R)-1-(1-Ethyl-1H-pyrazol-4-yl)-3-[5-(5-fluoro-2-pyridinyl)-1H-imidazol-2-yl]-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl}-3-methyl-1,3,4-oxadiazol-2(3H)-one |