(R)-2-(6-((2’,6’-Dimethyl-4’-(3-(Methylsulfonyl)Propoxy)-[1,1’-Biphenyl]-3-Yl)Methoxy)-2,3-Dihydrobenzofuran-3-Yl)Acetic Acid

Modify Date: 2024-02-07 10:17:05

(R)-2-(6-((2’,6’-Dimethyl-4’-(3-(Methylsulfonyl)Propoxy)-[1,1’-Biphenyl]-3-Yl)Methoxy)-2,3-Dihydrobenzofuran-3-Yl)Acetic Acid structure	Common Name	(R)-2-(6-((2’,6’-Dimethyl-4’-(3-(Methylsulfonyl)Propoxy)-[1,1’-Biphenyl]-3-Yl)Methoxy)-2,3-Dihydrobenzofuran-3-Yl)Acetic Acid
	CAS Number	1234474-57-7	Molecular Weight	524.63
	Density	1.3±0.1 g/cm3	Boiling Point	739.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₂O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	400.8±32.9 °C

Use of (R)-2-(6-((2’,6’-Dimethyl-4’-(3-(Methylsulfonyl)Propoxy)-[1,1’-Biphenyl]-3-Yl)Methoxy)-2,3-Dihydrobenzofuran-3-Yl)Acetic Acid

(R)-Fasiglifam is the inactive isomer of Fasiglifam (HY-10480), and can be used as an experimental control. Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.

Name	[(3R)-6-({2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]-3-biphenylyl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Synonym	More Synonyms

Description	(R)-Fasiglifam is the inactive isomer of Fasiglifam (HY-10480), and can be used as an experimental control. Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Nagatake T, et al. 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2017 Dec 26. pii: S0091-6749(17)32949-4. [2]. Yoshiyuki Tsujihata, et al. TAK-875, an Orally Available GPR40/FFA1 Agonist Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats. JPET July 13, 2011 [3]. Tsujihata Y,et al. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.J Pharmacol Exp [4]. Urano Y, et al. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice. Chem Biol Interact. 2018 Sep 20;296:185-197.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. Nagatake T, et al. 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2017 Dec 26. pii: S0091-6749(17)32949-4.

[2]. Yoshiyuki Tsujihata, et al. TAK-875, an Orally Available GPR40/FFA1 Agonist Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats. JPET July 13, 2011

[3]. Tsujihata Y,et al. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.J Pharmacol Exp

[4]. Urano Y, et al. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice. Chem Biol Interact. 2018 Sep 20;296:185-197.

Density	1.3±0.1 g/cm3
Boiling Point	739.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₂O₇S
Molecular Weight	524.63
Flash Point	400.8±32.9 °C
Exact Mass	524.186890
LogP	4.36
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.587

3-Benzofuranacetic acid, 6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-, (3R)-

[(3R)-6-({2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]-3-biphenylyl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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(R)-2-(6-((2’,6’-Dimethyl-4’-(3-(Methylsulfonyl)Propoxy)-[1,1’-Biphenyl]-3-Yl)Methoxy)-2,3-Dihydrobenzofuran-3-Yl)Acetic Acid

Use of (R)-2-(6-((2’,6’-Dimethyl-4’-(3-(Methylsulfonyl)Propoxy)-[1,1’-Biphenyl]-3-Yl)Methoxy)-2,3-Dihydrobenzofuran-3-Yl)Acetic Acid

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Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.