EL-102
Modify Date: 2024-01-09 12:52:28
EL-102 structure
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Common Name | EL-102 | ||
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| CAS Number | 1233948-61-2 | Molecular Weight | 384.472 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 548.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C19H16N2O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 285.3±32.9 °C | |
Use of EL-102EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.target: HIF1αIC 50：20-40 nM.[1]in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI-stained cells cultured for 24, 48 and 72?h, following treatment. EL102 induces apoptosis and causes G2/M arrest, preventing the cell from entering into mitosis.In vivo: CWR22 tumours were taken from an in vivo passage, cut into small fragments and transplanted subcutaneously (s.c.) into the flank of 48 nude mice. At day 13, when the tumours were palpable, mice were randomised into 10 groups with 8 mice each and treatment initiated. EL102 12?mg?kg?1 via p.o. (0700 hours and 1700 hours daily).[1] |
| Name | N-[5-(5-Cyano-3-thienyl)-2-methylphenyl]-4-methoxybenzenesulfonamide |
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| Synonym | More Synonyms |
| Description | EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.target: HIF1αIC 50：20-40 nM.[1]in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI-stained cells cultured for 24, 48 and 72?h, following treatment. EL102 induces apoptosis and causes G2/M arrest, preventing the cell from entering into mitosis.In vivo: CWR22 tumours were taken from an in vivo passage, cut into small fragments and transplanted subcutaneously (s.c.) into the flank of 48 nude mice. At day 13, when the tumours were palpable, mice were randomised into 10 groups with 8 mice each and treatment initiated. EL102 12?mg?kg?1 via p.o. (0700 hours and 1700 hours daily).[1] |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 548.1±60.0 °C at 760 mmHg |
| Molecular Formula | C19H16N2O3S2 |
| Molecular Weight | 384.472 |
| Flash Point | 285.3±32.9 °C |
| Exact Mass | 384.060242 |
| LogP | 5.01 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.669 |
| Storage condition | 2-8℃ |
| N-[5-(5-Cyano-3-thiényl)-2-méthylphényl]-4-méthoxybenzènesulfonamide |
| Benzenesulfonamide, N-[5-(5-cyano-3-thienyl)-2-methylphenyl]-4-methoxy- |
| N-[5-(5-Cyano-3-thienyl)-2-methylphenyl]-4-methoxybenzenesulfonamide |
| N-[5-(5-Cyan-3-thienyl)-2-methylphenyl]-4-methoxybenzolsulfonamid |
| EL-102 |