1233948-61-2

1233948-61-2 structure

Name: EL-102
Chemical Name: N-[5-(5-Cyano-3-thienyl)-2-methylphenyl]-4-methoxybenzenesulfonamide
CAS Number: 1233948-61-2
Molecular Formula: C₁₉H₁₆N₂O₃S₂
Molecular Weight: 384.472
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2018-04-25 20:49:44
Modify Date: 2024-01-09 12:52:28
EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.target: HIF1αIC 50：20-40 nM.[1]in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI-stained cells cultured for 24, 48 and 72?h, following treatment. EL102 induces apoptosis and causes G2/M arrest, preventing the cell from entering into mitosis.In vivo: CWR22 tumours were taken from an in vivo passage, cut into small fragments and transplanted subcutaneously (s.c.) into the flank of 48 nude mice. At day 13, when the tumours were palpable, mice were randomised into 10 groups with 8 mice each and treatment initiated. EL102 12?mg?kg?1 via p.o. (0700 hours and 1700 hours daily).[1]

Name	N-[5-(5-Cyano-3-thienyl)-2-methylphenyl]-4-methoxybenzenesulfonamide
Synonyms	N-[5-(5-Cyano-3-thiényl)-2-méthylphényl]-4-méthoxybenzènesulfonamide Benzenesulfonamide, N-[5-(5-cyano-3-thienyl)-2-methylphenyl]-4-methoxy- N-[5-(5-Cyano-3-thienyl)-2-methylphenyl]-4-methoxybenzenesulfonamide N-[5-(5-Cyan-3-thienyl)-2-methylphenyl]-4-methoxybenzolsulfonamid EL-102

Description	EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.target: HIF1αIC 50：20-40 nM.[1]in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI-stained cells cultured for 24, 48 and 72?h, following treatment. EL102 induces apoptosis and causes G2/M arrest, preventing the cell from entering into mitosis.In vivo: CWR22 tumours were taken from an in vivo passage, cut into small fragments and transplanted subcutaneously (s.c.) into the flank of 48 nude mice. At day 13, when the tumours were palpable, mice were randomised into 10 groups with 8 mice each and treatment initiated. EL102 12?mg?kg?1 via p.o. (0700 hours and 1700 hours daily).[1]
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Cancer
References	[1]. A P Toner et al. The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivoactivity against prostate cancer and circumvents MDR1 resistance. Br J Cancer, 2013 Oct 15, 109(8): 2131-2141.