Modipafant
Modify Date: 2025-12-08 10:17:20
Modipafant structure
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Common Name | Modipafant | ||
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| CAS Number | 122957-06-6 | Molecular Weight | 605.08500 | |
| Density | 1.34g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C34H29ClN6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ModipafantModipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505[1][2]. |
| Name | ethyl (4R)-4-(2-chlorophenyl)-6-methyl-2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate |
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| Synonym | More Synonyms |
| Description | Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505[1][2]. |
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| Related Catalog | |
| In Vitro | when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC50=5.6 nM) to 60 min (IC50=0.34 nM)[2]. |
| References |
| Density | 1.34g/cm3 |
|---|---|
| Molecular Formula | C34H29ClN6O3 |
| Molecular Weight | 605.08500 |
| Exact Mass | 604.19900 |
| PSA | 111.03000 |
| LogP | 6.75300 |
| InChIKey | ODRYSCQFUGFOSU-SSEXGKCCSA-N |
| SMILES | CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl |
| Modipafant |
| QCR-95 |
| UNII-1DMI0E5023 |