Modipafant

Names

[ Name ]:
Modipafant

[Synonym ]:
Modipafant
QCR-95
UNII-1DMI0E5023

Biological Activity

[Description]:

Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC50=5.6 nM) to 60 min (IC50=0.34 nM)[2].

[References]

[1]. Kuitert LM, et al. Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. Am J Respir Crit Care Med. 1995;151(5):1331-1335.

[2]. Jezequel SG, et al, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man. Xenobiotica. 1996;26(9):963-975.

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Molecular Formula ]:
C₃₄H₂₉ClN₆O₃

[ Molecular Weight ]:
605.08500

[ Exact Mass ]:
604.19900

[ PSA ]:
111.03000

[ LogP ]:
6.75300

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.