Ampreloxetine
Modify Date: 2024-01-06 18:58:02
Ampreloxetine structure
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Common Name | Ampreloxetine | ||
|---|---|---|---|---|
| CAS Number | 1227056-84-9 | Molecular Weight | 321.337 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 418.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H18F3NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 207.1±28.7 °C | |
Use of AmpreloxetineAmpreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively; displays an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporter; engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7 ng/mL and 50.8 ng/mL, respectively; TD-9855 is an investigational dual norepinephrine (NE) and serotonin (5-HT) reuptake inhibitor with selectivity for NE over 5-HT (NSRI). Other Indication Phase 2 Clinical |
| Name | Ampreloxetine |
|---|---|
| Synonym | More Synonyms |
| Description | Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively; displays an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporter; engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7 ng/mL and 50.8 ng/mL, respectively; TD-9855 is an investigational dual norepinephrine (NE) and serotonin (5-HT) reuptake inhibitor with selectivity for NE over 5-HT (NSRI). Other Indication Phase 2 Clinical |
|---|---|
| References | References 1. Smith JA, et al. Int J Neuropsychopharmacol. 2014 Dec 13;18(2). pii: pyu027. View Related Products by Target Monoamine Transporter Other Indication |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 418.9±45.0 °C at 760 mmHg |
| Molecular Formula | C18H18F3NO |
| Molecular Weight | 321.337 |
| Flash Point | 207.1±28.7 °C |
| Exact Mass | 321.134064 |
| LogP | 4.20 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.533 |
| Piperidine, 4-[2-[(2,4,6-trifluorophenoxy)methyl]phenyl]- |
| 4-{2-[(2,4,6-Trifluorophenoxy)methyl]phenyl}piperidine |
| Ampreloxetine |