Ampreloxetine

Names

[ Name ]:
Ampreloxetine

[Synonym ]:
Piperidine, 4-[2-[(2,4,6-trifluorophenoxy)methyl]phenyl]-
4-{2-[(2,4,6-Trifluorophenoxy)methyl]phenyl}piperidine
Ampreloxetine

Biological Activity

[Description]:

Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively; displays an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporter; engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7 ng/mL and 50.8 ng/mL, respectively; TD-9855 is an investigational dual norepinephrine (NE) and serotonin (5-HT) reuptake inhibitor with selectivity for NE over 5-HT (NSRI). Other Indication Phase 2 Clinical

[References]

References 1. Smith JA, et al. Int J Neuropsychopharmacol. 2014 Dec 13;18(2). pii: pyu027. View Related Products by Target Monoamine Transporter Other Indication

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
418.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₈F₃NO

[ Molecular Weight ]:
321.337

[ Flash Point ]:
207.1±28.7 °C

[ Exact Mass ]:
321.134064

[ LogP ]:
4.20

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.533

Related Compounds

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