AT791
Modify Date: 2025-09-18 17:56:15
AT791 structure
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Common Name | AT791 | ||
|---|---|---|---|---|
| CAS Number | 1219962-49-8 | Molecular Weight | 397.519 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H31N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AT791AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo. |
| Name | AT791 |
|---|
| Description | AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo. |
|---|---|
| References | References 1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40. View Related Products by Target Toll-like Receptor (TLR) |
| Molecular Formula | C23H31N3O3 |
|---|---|
| Molecular Weight | 397.519 |
| InChIKey | JKFYWFWUJUHSMZ-UHFFFAOYSA-N |
| SMILES | CN(C)CCCOc1ccc(-c2nc3ccc(OCCCN(C)C)cc3o2)cc1 |