AT791

Names

[ CAS No. ]:
1219962-49-8

[ Name ]:
AT791

Biological Activity

[Description]:

AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.

[References]

References 1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40. View Related Products by Target Toll-like Receptor (TLR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₁N₃O₃

[ Molecular Weight ]:
397.519

Related Compounds

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