Junceellolide C
Modify Date: 2024-01-12 21:02:23
Junceellolide C structure
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Common Name | Junceellolide C | ||
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| CAS Number | 121769-82-2 | Molecular Weight | 540.99 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H33ClO10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Junceellolide CJunceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent[1]. |
| Name | Junceellolide C |
|---|
| Description | Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent[1]. |
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| Related Catalog | |
| Target |
EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells[1] |
| In Vitro | Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC50 values of 2.27, 3.52 μM, respectively[1]. Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation[1]. Cell Viability Assay[1] Cell Line: HepAD38 cells Concentration: 10 μM Incubation Time: 72 h, 8 days Result: Inhibited cccDNA transcription. |
| References |
| Molecular Formula | C26H33ClO10 |
|---|---|
| Molecular Weight | 540.99 |