Junceellolide C

Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent[1].

Signaling Pathways >> Anti-infection >> HBV

Research Areas >> Inflammation/Immunology

EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells[1]

Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC50 values of 2.27, 3.52 μM, respectively[1]. Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation[1]. Cell Viability Assay[1] Cell Line: HepAD38 cells Concentration: 10 μM Incubation Time: 72 h, 8 days Result: Inhibited cccDNA transcription.

[1]. Jiru Wu, et al. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. with anti-HBV activities. Bioorg Chem. 2020 Dec;105:104423.