N(1),N(11)-Diethylnorspermine tetrahydrochloride

Modify Date: 2025-08-25 11:25:25

N(1),N(11)-Diethylnorspermine tetrahydrochloride structure	Common Name	N(1),N(11)-Diethylnorspermine tetrahydrochloride
	CAS Number	121749-39-1	Molecular Weight	244.42
	Density	0.877 g/cm3	Boiling Point	357.1ºC at 760 mmHg
	Molecular Formula	C₁₃H₃₂N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	171.9ºC

Use of N(1),N(11)-Diethylnorspermine tetrahydrochloride

N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3].

Name	N1,N11-Diethylnorspermine tetrahydrochloride,N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediaminetetrahydrochloride
Synonym	More Synonyms

Description	N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase 3
In Vivo	N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line[1].
References	[1]. Schipper RG, et al. Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. Prostate. 2000 Sep 1;44(4):313-21. [2]. Holst CM, et al. Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. Anticancer Drugs. 2008 Oct;19(9):871-83. [3]. Jiang R, et al. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. Int J Oncol. 2007 Aug;31(2):431-40.

Density	0.877 g/cm3
Boiling Point	357.1ºC at 760 mmHg
Molecular Formula	C₁₃H₃₂N₄
Molecular Weight	244.42
Flash Point	171.9ºC
Exact Mass	388.16900
PSA	48.12000
LogP	5.32650
Vapour Pressure	2.79E-05mmHg at 25°C
Index of Refraction	1.462

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX7032250

CHEMICAL NAME :: 1,3-Propanediamine, N,N'-bis(3-(ethylamino)propyl)-

CAS REGISTRY NUMBER :: 121749-39-1

LAST UPDATED :: 199510

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H32-N4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTDEV Anti-Cancer Drugs. (Rapid Communications of Oxford Ltd., The Old Malthous, Paradise St., Oxford OX1 1LD, UK) V.1- 1990- Volume(issue)/page/year: 5,448,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 37,3464,1994

Bisethyl norspermine

denspm

de333

be3-3-3

3,7,11,15-Tetraazaheptadecane

N1,N11-Diethylnorspermine4HCl

N1,N11-Diethylnorspermine tetrahydrochloride

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: N1,N11-Diethylnorspermine
Price: Check
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China
Product Name: N(1),N(11)-Diethylnorspermine tetrahydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
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DC Chemicals Limited
China
Product Name: N(1),N(11)-Diethylnorspermine tetrahydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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