121749-39-1

121749-39-1 structure

Name: N(1),N(11)-Diethylnorspermine tetrahydrochloride
Chemical Name: N1,N11-Diethylnorspermine tetrahydrochloride,N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediaminetetrahydrochloride
CAS Number: 121749-39-1
Molecular Formula: C₁₃H₃₂N₄
Molecular Weight: 244.42
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-06-21 17:23:28
Modify Date: 2025-08-25 11:25:25
N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3].

Name	N1,N11-Diethylnorspermine tetrahydrochloride,N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediaminetetrahydrochloride
Synonyms	Bisethyl norspermine denspm de333 be3-3-3 3,7,11,15-Tetraazaheptadecane N1,N11-Diethylnorspermine4HCl N1,N11-Diethylnorspermine tetrahydrochloride

Description	N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase 3
In Vivo	N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line[1].
References	[1]. Schipper RG, et al. Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. Prostate. 2000 Sep 1;44(4):313-21. [2]. Holst CM, et al. Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. Anticancer Drugs. 2008 Oct;19(9):871-83. [3]. Jiang R, et al. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. Int J Oncol. 2007 Aug;31(2):431-40.

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTDEV Anti-Cancer Drugs. (Rapid Communications of Oxford Ltd., The Old Malthous, Paradise St., Oxford OX1 1LD, UK) V.1- 1990- Volume(issue)/page/year: 5,448,1994

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 37,3464,1994