Ertugliflozin
Modify Date: 2024-01-02 20:30:06
Ertugliflozin structure
|
Common Name | Ertugliflozin | ||
|---|---|---|---|---|
| CAS Number | 1210344-57-2 | Molecular Weight | 436.883 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 630.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H25ClO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 335.1±31.5 °C | |
Use of ErtugliflozinErtugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2]. |
| Name | (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol |
|---|---|
| Synonym | More Synonyms |
| Description | Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.877 nM (h-SGLT2)[1]. |
| In Vitro | Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3]. |
| In Vivo | Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats[3]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 630.5±55.0 °C at 760 mmHg |
| Molecular Formula | C22H25ClO7 |
| Molecular Weight | 436.883 |
| Flash Point | 335.1±31.5 °C |
| Exact Mass | 436.128876 |
| PSA | 108.61000 |
| LogP | 6.49 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.652 |
| Storage condition | -20℃ |
|
~28%
Ertugliflozin CAS#:1210344-57-2 |
| Literature: WO2010/23594 A1, ; Page/Page column 64-66 ; |
|
~%
Ertugliflozin CAS#:1210344-57-2 |
| Literature: Organic Letters, , vol. 12, # 13 p. 2940 - 2943 |
![{(2S,3S)-3,4,5-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6,8-dioxa-bicyclo[3.2.1]oct-1-yl}-methanol structure](https://www.chemsrc.com/caspic/460/1210763-25-9.png)
![(1S,2S,3S,4S,5S)-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1-hydroxymethyl-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol structure](https://www.chemsrc.com/caspic/251/1210344-58-3.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| (1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol |
| Ertugliflozin |
| PF-04971729 |
| Ertugliflozin (USAN/INN) |
| PF-04971729-00 |
| MK-8835 |
| cc-212 |
| (1S,2S,3S,4R,5S)-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1-hydroxymethyl-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol |
- DC Chemicals Limited
- China
- Product Name: PF-04971729 (Ertugliflozin)
- Price: $450.0/100mg $850.0/250mg $1700.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: PF-04971729 PF04971729
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: PF-04971729
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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