VGSCs-IN-1

Modify Date: 2025-11-03 10:39:57

VGSCs-IN-1 structure	Common Name	VGSCs-IN-1
	CAS Number	1204296-79-6	Molecular Weight	303.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₂F₃N₃OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VGSCs-IN-1

VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research[1].

Name	2-(piperazin-1-yl)-6-(trifluoromethoxy)benzothiazole

Description	VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	hNav1.4 hNav1.7
References	[1]. Farinato A, et al. Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels. ACS Med Chem Lett. 2023 Jun 23;14(7):999-1008.

Molecular Formula	C₁₂H₁₂F₃N₃OS
Molecular Weight	303.30
Exact Mass	303.06500
PSA	65.63000
LogP	2.99830
InChIKey	IFWQLRCODRPXKE-UHFFFAOYSA-N
SMILES	FC(F)(F)Oc1ccc2nc(N3CCNCC3)sc2c1

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-PIPERAZIN-1-YL-6-(TRIFLUOROMETHOXY)-1,3-BENZOTHIAZOLE
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

VGSCs-IN-1 suppliers

VGSCs-IN-1 price

VGSCs-IN-1

Use of VGSCs-IN-1

Names

VGSCs-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.