CAY10626
Modify Date: 2025-08-25 20:06:31
CAY10626 structure
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Common Name | CAY10626 | ||
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| CAS Number | 1202884-94-3 | Molecular Weight | 624.657 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C31H35F3N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CAY10626PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer[1]. |
| Name | N-[2-(dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide |
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| Synonym | More Synonyms |
| Description | PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
PI3Kα:0.9 nM (IC50) mTOR:0.6 nM (IC50) |
| In Vitro | PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of <3.0 and 13.0 nM[1]. |
| In Vivo | PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in nude mouse[1]. PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) exhibits significant tumor regression in 50 mg/kg and no tumor regrowth until day 32, and tumor growth inhibition in 25 and 10 mg/kg in MDA361 tumor xenograft nude mice model[1]. PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C31H35F3N8O3 |
| Molecular Weight | 624.657 |
| Exact Mass | 624.278442 |
| PSA | 107.86000 |
| LogP | 2.42 |
| Index of Refraction | 1.625 |
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~%
CAY10626 CAS#:1202884-94-3 |
| Literature: Wyeth Patent: US2010/3250 A1, 2010 ; Location in patent: Page/Page column 27 ; US 20100003250 A1 |
![4-({[4-(7-(2,2,2-trifluoroethyl)-4-morpholin-4-yl-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)phenyl]carbamoyl}amino)benzoic acid structure](https://image.chemsrc.com/caspic/432/1202885-81-1.png)
| Precursor 2 | |
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| DownStream 0 | |
| Benzamide, N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]- |
| N-[2-(Dimethylamino)ethyl]-N-methyl-4-[({4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide |