UNC 0224

Modify Date: 2025-08-21 19:38:08

UNC 0224 structure	Common Name	UNC 0224
	CAS Number	1197196-48-7	Molecular Weight	485.665
	Density	1.1±0.1 g/cm3	Boiling Point	641.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₄₃N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	341.5±34.3 °C

Use of UNC 0224

UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in the G9a Thioglo assay.IC50 value: 15 nM [1]Target: G9aUNC0224 (Compound 8) also potently inhibited GLP with an IC50 of 20 nM and 58 nM in the Thioglo assay and and AlphaScreen, respectively. 8 was more than 1000-fold selective for G9a over SET7/9 (a H3K4 HMT) and SET8/PreSET7 (a H4K20 HMT) in Thioglo-based biochemical assays [1] [2].

Name	7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Synonym	More Synonyms

Description	UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in the G9a Thioglo assay.IC50 value: 15 nM [1]Target: G9aUNC0224 (Compound 8) also potently inhibited GLP with an IC50 of 20 nM and 58 nM in the Thioglo assay and and AlphaScreen, respectively. 8 was more than 1000-fold selective for G9a over SET7/9 (a H3K4 HMT) and SET8/PreSET7 (a H4K20 HMT) in Thioglo-based biochemical assays [1] [2].
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer
References	[1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3. [2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

Description

Related Catalog

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Cancer

References

[1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3.

[2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

Density	1.1±0.1 g/cm3
Boiling Point	641.0±65.0 °C at 760 mmHg
Molecular Formula	C₂₆H₄₃N₇O₂
Molecular Weight	485.665
Flash Point	341.5±34.3 °C
Exact Mass	485.347809
PSA	69.23000
LogP	1.30
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.589
Storage condition	2-8℃

3-Dimethylamino...

CAS#:3179-63-3

6-methoxy-2-(4-...

CAS#:1238673-02-3

UNC 0224

CAS#:1197196-48-7

Literature: Liu, Feng; Chen, Xin; Allali-Hassani, Abdellah; Quinn, Amy M.; Wigle, Tim J.; Wasney, Gregory A.; Dong, Aiping; Senisterra, Guillermo; Chau, Irene; Siarheyeva, Alena; Norris, Jacqueline L.; Kireev, Dmitri B.; Jadhav, Ajit; Herold, J. Martin; Janzen, William P.; Arrowsmith, Cheryl H.; Frye, Stephen V.; Brown, Peter J.; Simeonov, Anton; Vedadi, Masoud; Jin, Jian Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5844 - 5857

Precursor 2
CAS#:3179-63-3 3-Dimethylamino... CAS#:1238673-02-3 6-methoxy-2-(4-...
DownStream 0

7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

4-quinazolinamine, 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-

7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

unc0224

UNC-0224

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UNC0224
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: UNC-0224
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: UNC-0224
Price: $550.0/100mg $950.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: $128/10mM*1mLinDMSO

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UNC 0224

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.