UNC-926
Modify Date: 2024-01-09 21:28:00
UNC-926 structure
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Common Name | UNC-926 | ||
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| CAS Number | 1184136-10-4 | Molecular Weight | 337.25500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H21BrN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of UNC-926UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM. |
| Name | (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone |
|---|---|
| Synonym | More Synonyms |
| Description | UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM. |
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| Related Catalog | |
| Target |
IC50: 3.9 μM (L3MBTL1)[1] |
| In Vitro | UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1]. |
| References |
| Molecular Formula | C16H21BrN2O |
|---|---|
| Molecular Weight | 337.25500 |
| Exact Mass | 336.08400 |
| PSA | 23.55000 |
| LogP | 3.02530 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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| UNC 926 hydrochloride |
| UNC-926 |