TAK-259
Modify Date: 2025-09-10 20:50:03
TAK-259 structure
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Common Name | TAK-259 | ||
|---|---|---|---|---|
| CAS Number | 1192348-73-4 | Molecular Weight | 374.236 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H13Cl2N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TAK-259A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats. Other Indication Phase 1 Discontinued |
| Name | TAK-259 |
|---|
| Description | A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats. Other Indication Phase 1 Discontinued |
|---|---|
| References | References 1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002. View Related Products by Target Adrenergic Receptor Other Indication |
| Molecular Formula | C14H13Cl2N3O3S |
|---|---|
| Molecular Weight | 374.236 |
| InChIKey | CVBJUEIAUOTXLV-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)c1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N |