3,3'-dimethylbenzidine

Modify Date: 2025-08-23 12:07:17

3,3'-dimethylbenzidine structure	Common Name	3,3'-dimethylbenzidine
	CAS Number	119-93-7	Molecular Weight	212.290
	Density	1.1±0.1 g/cm3	Boiling Point	361.0±37.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆N₂	Melting Point	128-131 °C(lit.)
	MSDS	Chinese USA	Flash Point	205.1±26.0 °C
	Symbol	GHS07, GHS08, GHS09	Signal Word	Danger

Name	c.i. 37230
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	361.0±37.0 °C at 760 mmHg
Melting Point	128-131 °C(lit.)
Molecular Formula	C₁₄H₁₆N₂
Molecular Weight	212.290
Flash Point	205.1±26.0 °C
Exact Mass	212.131348
PSA	52.04000
LogP	2.48
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.638
Water Solubility	2% HCl: 10 mg/mL, clear

3,3'-dimethylbenzidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD1225000

CHEMICAL NAME :: Benzidine, 3,3'-dimethyl-

CAS REGISTRY NUMBER :: 119-93-7

BEILSTEIN REFERENCE NO. :: 2210640

LAST UPDATED :: 199712

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C14-H16-N2

MOLECULAR WEIGHT :: 212.32

WISWESSER LINE NOTATION :: ZR B1 DR DZ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/kg/27D-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1650 mg/kg/33W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5040 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 gm/kg/51W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5040 mg/kg/56W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Endocrine - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3240 mg/kg/34W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - rabbit Lymphocyte

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,197,1981 *** REVIEWS *** ACGIH TLV-Animal carcinogen, NO TWA (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,87,1972 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,87,1972 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-TOLIDINE-air:CA CL 0.02 mg/m3/60M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84756 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 421 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84756 No. of Facilities: 854 (estimated) No. of Industries: 8 No. of Occupations: 20 No. of Employees: 9640 (estimated) No. of Female Employees: 6005 (estimated)

Symbol	GHS07, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H302-H350-H411
Precautionary Statements	P201-P273-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R22;R45;R51/53;R68
Safety Phrases	53-45-61
RIDADR	UN 3082 9/PG 3
WGK Germany	3
RTECS	DD1225000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29309070

Precursor 10
CAS#:615-37-2 4-Iodotoluene CAS#:88-72-2 2-Nitrotoluene CAS#:15403-45-9 33DICARBOMETHOX... CAS#:584-90-7 Diazene,1,2-bis...
CAS#:2130-56-5 2-amino-5-(4-am... CAS#:617-22-1 1,2-Bis(2-methy... CAS#:95-53-4 o-Toluidine CAS#:83-83-0 [1,1'-Biphenyl]...
CAS#:7732-18-5 Water CAS#:7782-99-2 Sulfurous Acid
DownStream 8
CAS#:91-96-3 N,N'-Bis(acetoa... CAS#:612-75-9 3,3'-Dimethylbi... CAS#:13629-82-8 3,3'-Dimethyl-4... CAS#:48172-89-0 4-(4-amino-3-br...
CAS#:584-70-3 Benzamide,N-(2-... CAS#:61794-96-5 4,4'-DIBROMO-3,... CAS#:6324-67-0 Benzenesulfonam... CAS#:63297-02-9 3,3'-Dimethyl-[...

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.

Environ. Mol. Mutagen. 48(5) , 404-13, (2007)

4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...

Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

Eur. J. Med. Chem. 42 , 1396-402, (2007)

Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...

ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives.

Mutat. Res. 319(1) , 19-30, (1993)

Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobe...

orthotolidine

3,3'-Dimethylbenzidine 4,4'-Bianisidine

Ellms-Hauser

3,3'-Dimethyl-4,4'-biphenyldiamine

o-Tolidin

2-Tolidina

3,3'-Tolidine

2-Tolidine

[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-

DMB

o-Tolidine (3,3'-Dimethylbenzidine)

diaminotolyl

2-Tolidin

4,4'-Diamino-3,3'-dimethylbiphenyl

3,3'-dimethylbiphenyl-4,4'-diamine

o-Tolidine,pract

EINECS 204-358-0

Tolidine

3,3'-dimethyl-4,4'-diamino-biphenyl

3,3'-dimethylbenzidine

MFCD00014773

o-tolidine

3,3'-dimethyl-[1,1'-biphenyl]-4,4'-diamine

bianisidine

ο-Tolidine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3,3'-dimethylbenzidine
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3,3'-dimethylbenzidine
Price: ￥248.0/100g ￥88.0/25g
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,3'-Dimethylbenzidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: c.i. 37230
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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3,3'-dimethylbenzidine

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