Mefenamic Acid-d3

Modify Date: 2024-01-09 15:27:39

Mefenamic Acid-d3 structure	Common Name	Mefenamic Acid-d3
	CAS Number	1189707-81-0	Molecular Weight	244.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₂D₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mefenamic Acid-d3

Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

Name	Mefenamic Acid-d3

Description	Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [3]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

Molecular Formula	C₁₅H₁₂D₃NO₂
Molecular Weight	244.30

Mefenamic Acid-d3

Use of Mefenamic Acid-d3

Names

Mefenamic Acid-d3 Biological Activity

Chemical & Physical Properties