Probenecid-d14

Modify Date: 2023-01-16 10:21:32

Probenecid-d14 structure	Common Name	Probenecid-d14
	CAS Number	1189657-87-1	Molecular Weight	299.445
	Density	1.2±0.1 g/cm3	Boiling Point	438.0±47.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₅D₁₄NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	218.7±29.3 °C

Use of Probenecid-d14

Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

Name	Probenecid-d14
Synonym	More Synonyms

Description	Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Signaling Pathways >> Anti-infection >> HIV Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. [3]. Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. [4]. Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123. [5]. Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7.

Density	1.2±0.1 g/cm3
Boiling Point	438.0±47.0 °C at 760 mmHg
Molecular Formula	C₁₃H₅D₁₄NO₄S
Molecular Weight	299.445
Flash Point	218.7±29.3 °C
Exact Mass	299.191345
LogP	3.30
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.542

4-{Bis[(2H7)propyl]sulfamoyl}benzoic acid

Benzoic acid, 4-[(dipropyl-d7-amino)sulfonyl]-

PROBENECID-D14

Probenecid-d14

Use of Probenecid-d14

Names

Probenecid-d14 Biological Activity

Chemical & Physical Properties

Synonyms