D-Mannitol,1,6-dimethanesulfonate

Modify Date: 2024-01-11 22:32:26

D-Mannitol,1,6-dimethanesulfonate Structure
D-Mannitol,1,6-dimethanesulfonate structure
Common Name D-Mannitol,1,6-dimethanesulfonate
CAS Number 1187-00-4 Molecular Weight 338.35300
Density 1.635g/cm3 Boiling Point 721.3ºC at 760 mmHg
Molecular Formula C8H18O10S2 Melting Point 134-136 °C
MSDS N/A Flash Point 390ºC

 Names

Name D-Mannitol,1,6-dimethanesulfonate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.635g/cm3
Boiling Point 721.3ºC at 760 mmHg
Melting Point 134-136 °C
Molecular Formula C8H18O10S2
Molecular Weight 338.35300
Flash Point 390ºC
Exact Mass 338.03400
PSA 184.42000
Vapour Pressure 5.01E-24mmHg at 25°C
Index of Refraction 1.553

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OP2975000
CHEMICAL NAME :
Mannitol, 1,6-dimethanesulfonate, D-
CAS REGISTRY NUMBER :
1187-00-4
LAST UPDATED :
199707
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C8-H18-O10-S2
MOLECULAR WEIGHT :
338.38
WISWESSER LINE NOTATION :
WS1&O1YQYQYQYQ1OSW1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Blood - normocytic anemia Blood - thrombocytopenia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - agranulocytosis Blood - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - agranulocytosis Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 mg/kg/4W
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rabbit Bone marrow
DOSE/DURATION :
1700 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976

 Safety Information

HS Code 2905499000

 Customs

HS Code 2905499000
Summary 2905499000 other polyhydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

O1,O6-Dimethansulfonyl-D-mannit
Mannogranol
D-Mannitol busulphan
D-Mannitol busulfan
O1,O6-bis-methanesulfonyl-D-mannitol
1,6-Bis-methansulfonyl-D-mannit
MANNITOL,1,6-DIMETHYLSULPHONATE,D
1,6-Di-O-methansulfonyl-D-mannitol
2511 C. B.
O1,O6-Bis-methansulfonyl-D-mannit
1,6-Dimethanesulfonate-D-mannitol
1,6-Bis-methansulfonyloxy-D-manno-hexan-2,3,4,5-tetraol
1,6-Dimesyl-D-mannitol
1,6-Di-O-methansulfonyl-D-mannit
1,6-Dimethanesulfonoxy-D-mannitol