(3,4,5-Trihydroxybenzylidene)malononitrile
Modify Date: 2024-01-08 15:42:31
(3,4,5-Trihydroxybenzylidene)malononitrile structure
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Common Name | (3,4,5-Trihydroxybenzylidene)malononitrile | ||
|---|---|---|---|---|
| CAS Number | 118409-58-8 | Molecular Weight | 202.17 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 500.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C10H6N2O3 | Melting Point | -220ºC dec. | |
| MSDS | N/A | Flash Point | 256.7±30.1 °C | |
Use of (3,4,5-Trihydroxybenzylidene)malononitrileTyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC50 of 0.94 µM and an EC50 of 5.3 µM[1][2]. |
| Name | tyrphostin a25 |
|---|---|
| Synonym | More Synonyms |
| Description | Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC50 of 0.94 µM and an EC50 of 5.3 µM[1][2]. |
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| Related Catalog | |
| Target |
EGFR tyrosine kinase[1] IC50: 0.94 µM (GPR35)[2] EC50: 5.3 µM (GPR35)[2] |
| References |
[2]. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585(12):1957-62. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 500.8±50.0 °C at 760 mmHg |
| Melting Point | -220ºC dec. |
| Molecular Formula | C10H6N2O3 |
| Molecular Weight | 202.17 |
| Flash Point | 256.7±30.1 °C |
| Exact Mass | 202.037842 |
| PSA | 108.27000 |
| LogP | 0.55 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.743 |
| Storage condition | 2-8°C |
| Stability | Light Sensitive |
| Water Solubility | DMSO: >50 mg/mL, clear, yellow to orange |
| WGK Germany | 3 |
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~85%
(3,4,5-Trihydro... CAS#:118409-58-8 |
| Literature: Hussoin; FitzGerald; Wick Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 5 p. 416 - 418 |
|
~%
(3,4,5-Trihydro... CAS#:118409-58-8 |
| Literature: Justus Liebigs Annalen der Chemie, , vol. 437, p. 143 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| (3,4,5-trihydroxybenzylidene)propanedinitrile |
| tyrphostin A-25 |
| Propanedinitrile, 2-[(3,4,5-trihydroxyphenyl)methylene]- |
| TYROPHOSTIN A25 |
| TYRPHOSTIN 25 |
| (3,4,5-Trihydroxybenzylidene)malononitrile |