tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

Modify Date: 2025-08-25 09:17:36

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure
tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate structure
Common Name tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
CAS Number 1174020-40-6 Molecular Weight 219.253
Density 1.2±0.1 g/cm3 Boiling Point 300.8±42.0 °C at 760 mmHg
Molecular Formula C10H18FNO3 Melting Point N/A
MSDS N/A Flash Point 135.7±27.9 °C

 Names

Name (3S,4R)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 300.8±42.0 °C at 760 mmHg
Molecular Formula C10H18FNO3
Molecular Weight 219.253
Flash Point 135.7±27.9 °C
Exact Mass 219.127075
PSA 49.77000
LogP 0.57
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.478
InChIKey XRNLYXKYODGLMI-JGVFFNPUSA-N
SMILES CC(C)(C)OC(=O)N1CCC(O)C(F)C1

 Safety Information

HS Code 2933399090

 Synthetic Route

~76%

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure

tert-butyl (3S,...

CAS#:1174020-40-6

Literature: Shaw, Simon J.; Goff, Dane A.; Boralsky, Luke A.; Irving, Mark; Singh, Rajinder Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8892 - 8897

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tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure

tert-butyl (3S,...

CAS#:1174020-40-6

Literature: PFIZER INC.; GUIMARAES, Cristiano Ruch Werneck; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton, Jr. Patent: WO2011/36576 A1, 2011 ; WO 2011/036576 A1

~%

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure

tert-butyl (3S,...

CAS#:1174020-40-6

Literature: PFIZER INC.; GUIMARAES, Cristiano Ruch Werneck; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton, Jr. Patent: WO2011/36576 A1, 2011 ; WO 2011/036576 A1

~%

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure

tert-butyl (3S,...

CAS#:1174020-40-6

Literature: PFIZER INC.; GUIMARAES, Cristiano Ruch Werneck; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton, Jr. Patent: WO2011/36576 A1, 2011 ; WO 2011/036576 A1

~%

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure

tert-butyl (3S,...

CAS#:1174020-40-6

Literature: PFIZER INC.; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton Patent: WO2011/61679 A1, 2011 ; WO 2011/061679 A1

~%

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate Structure

tert-butyl (3S,...

CAS#:1174020-40-6

Literature: Shaw, Simon J.; Goff, Dane A.; Boralsky, Luke A.; Irving, Mark; Singh, Rajinder Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8892 - 8897

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Methyl-2-propanyl (3S,4R)-3-fluoro-4-hydroxy-1-piperidinecarboxylate
(3S,4R)-N-t-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid
1-Boc-3S-fluoro-4R-piperidinol
1-Piperidinecarboxylic acid, 3-fluoro-4-hydroxy-, 1,1-dimethylethyl ester, (3S,4R)-
1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid
(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)-pyrrolidine-3-carboxylic acid
tert-butyl cis-3-fluoro-4-hydroxy-piperidine-1-carboxylate
(3S,4R)-N-tert-butyl-4-(2,4-difluoro-phenyl)-pyrrolidine-3-carboxylic acid
(cis)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester
(3S,4R)-1-t-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid
tert-butyl (3,4-cis)-3-fluoro-4-hydroxypiperidine-1-carboxylate
tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
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