(5E)-BiMatoprost

Modify Date: 2025-08-25 18:54:07

(5E)-BiMatoprost Structure
(5E)-BiMatoprost structure
Common Name (5E)-BiMatoprost
CAS Number 1163135-95-2 Molecular Weight 415.57
Density 1.1±0.1 g/cm3 Boiling Point 629.8±55.0 °C at 760 mmHg
Molecular Formula C25H37NO4 Melting Point N/A
MSDS N/A Flash Point 334.7±31.5 °C

 Use of (5E)-BiMatoprost


5,6-trans-Bimatoprost is the inactive isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.

 Names

Name 5-trans-17-phenyl trinor Prostaglandin F2.α. ethyl amide
Synonym More Synonyms

 (5E)-BiMatoprost Biological Activity

Description 5,6-trans-Bimatoprost is the inactive isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
Related Catalog
References

[1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7.  

[2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 629.8±55.0 °C at 760 mmHg
Molecular Formula C25H37NO4
Molecular Weight 415.57
Flash Point 334.7±31.5 °C
Exact Mass 415.272247
PSA 89.79000
LogP 1.98
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.591

 Synthetic Route

~80%

(5E)-BiMatoprost Structure

(5E)-BiMatoprost

CAS#:1163135-95-2

Literature: Gutman, Arie; Rukhman, Igor; Tishin, Boris; Yudovich, Lev; Vilensky, Alexander; Pertsikov, Boris; Nisnevich, Gennady Patent: US2009/163596 A1, 2009 ; Location in patent: Page/Page column 17-18 ;

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(5E)-BiMatoprost Structure

(5E)-BiMatoprost

CAS#:1163135-95-2

Literature: ALLERGAN, INC. Patent: WO2003/74481 A2, 2003 ; Location in patent: Page/Page column 7 ;

 Synonyms

4-Androstene-3,17-dione-19-ol
15R-bimatoprost
19-hydroxyandrostenedione
4-androsten-19-ol-3,17-dione
(5E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamide
(5E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
19-Hydroxyandrostendione
5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5E)-
19-Hydroxy-androst-4-en-3,17-dion
15-epi-bimatoprost
19-Hydroxy-4-androstene-3,17-dione
5-trans bimatoprost
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