Breviscapin

Modify Date: 2024-01-02 16:49:57

Breviscapin Structure
Breviscapin structure
 Common Name Breviscapin
CAS Number 116122-36-2 Molecular Weight 1293.34
Density 1.81g/cm3 Boiling Point 891.6ºC at 760mmHg
Molecular Formula C54H84N16O21 Melting Point N/A
MSDS N/A Flash Point 314.9ºC

 Use of Breviscapin


Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris[1][2].

 Names

Name (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonym More Synonyms

 Breviscapin Biological Activity

Description Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris[1][2].
Related Catalog
References

[1]. Gao J, et al. Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review. Front Pharmacol. 2017 May 23;8:289.  

[2]. Wen L, et al. Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects. Am J Chin Med. 2021;49(6):1369-1397.  

 Chemical & Physical Properties

Density 1.81g/cm3
Boiling Point 891.6ºC at 760mmHg
Molecular Formula C54H84N16O21
Molecular Weight 1293.34
Flash Point 314.9ºC
Exact Mass 908.164734
PSA 394.47000
Vapour Pressure 3.91E-34mmHg at 25°C
Index of Refraction 1.763
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EE4750000
CHEMICAL NAME :
Breviscapine
CAS REGISTRY NUMBER :
116122-36-2
LAST UPDATED :
199503

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,33,1983

 Synonyms

Scutellarein-7beta-D-glucuronoside
Breviscapine
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-, compd. with 7-[(5ξ)-β-D-xylo-hexopyranuronosyloxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one ( 1:1)
Scutellarein-7-glucuronide
5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranosiduronic acid - 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl (5ξ)-β-D-xylo-hexopyranosiduronic acid (1:1)
Breviscapin
5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-chromen-7-yl |A-d-glucopyranosiduronic acid
Scutellarein-7beta-D-glucuronide
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Chemsrc provides Breviscapin(CAS#:116122-36-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Breviscapin are included as well.>> amp version: Breviscapin

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