Breviscapin

Names

[ Name ]:
Breviscapin

[Synonym ]:
Scutellarein-7beta-D-glucuronoside
Breviscapine
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-, compd. with 7-[(5ξ)-β-D-xylo-hexopyranuronosyloxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one ( 1:1)
Scutellarein-7-glucuronide
5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranosiduronic acid - 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl (5ξ)-β-D-xylo-hexopyranosiduronic acid (1:1)
Breviscapin
5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-chromen-7-yl |A-d-glucopyranosiduronic acid
Scutellarein-7beta-D-glucuronide

Biological Activity

[Description]:

Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Gao J, et al. Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review. Front Pharmacol. 2017 May 23;8:289.

[2]. Wen L, et al. Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects. Am J Chin Med. 2021;49(6):1369-1397.

Chemical & Physical Properties

[ Density]:
1.81g/cm3

[ Boiling Point ]:
891.6ºC at 760mmHg

[ Molecular Formula ]:
C₅₄H₈₄N₁₆O₂₁

[ Molecular Weight ]:
1293.34

[ Flash Point ]:
314.9ºC

[ Exact Mass ]:
908.164734

[ PSA ]:
394.47000

[ Vapour Pressure ]:
3.91E-34mmHg at 25°C

[ Index of Refraction ]:
1.763

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EE4750000

CHEMICAL NAME :: Breviscapine

CAS REGISTRY NUMBER :: 116122-36-2

LAST UPDATED :: 199503

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1314 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,33,1983