SKF96067

Modify Date: 2024-01-14 10:49:50

SKF96067 Structure
SKF96067 structure
Common Name SKF96067
CAS Number 115607-61-9 Molecular Weight 334.41200
Density 1.162g/cm3 Boiling Point 473.2ºC at 760mmHg
Molecular Formula C21H22N2O2 Melting Point N/A
MSDS N/A Flash Point 240ºC

 Use of SKF96067


SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.

 Names

Name 1-[8-methoxy-4-(2-methylanilino)quinolin-3-yl]butan-1-one
Synonym More Synonyms

 SKF96067 Biological Activity

Description SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.
Related Catalog
In Vitro SKF96067 inhibits K+-stimulated ATPase activity competitively with respect to the activating action K+, with a Ki value of 0.39 ± 0.05 μM. SKF96067 also inhibits hydrogen ion transport. SKF96067 inhibits ATPase activity with an IC50 value of 60 ± 10 μM at pH 7.0, in the presence of 100 mM NaCl and 1 mM KCl[1].
References

[1]. Keeling DJ, et al. SK&F 96067 is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem Pharmacol. 1991 Jun 21;42(1):123-30.

 Chemical & Physical Properties

Density 1.162g/cm3
Boiling Point 473.2ºC at 760mmHg
Molecular Formula C21H22N2O2
Molecular Weight 334.41200
Flash Point 240ºC
Exact Mass 334.16800
PSA 51.22000
LogP 5.35120
Vapour Pressure 4E-09mmHg at 25°C
Index of Refraction 1.63
Storage condition 2-8℃

 Synonyms

SKF96067
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