4-hydroxy-3-phenyl-naphthalene-1,2-dione
Modify Date: 2025-08-27 16:25:53
4-hydroxy-3-phenyl-naphthalene-1,2-dione structure
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Common Name | 4-hydroxy-3-phenyl-naphthalene-1,2-dione | ||
|---|---|---|---|---|
| CAS Number | 1150-59-0 | Molecular Weight | 250.24900 | |
| Density | 1.392g/cm3 | Boiling Point | 445.3ºC at 760 mmHg | |
| Molecular Formula | C16H10O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 237.2ºC | |
Use of 4-hydroxy-3-phenyl-naphthalene-1,2-dioneAntimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent[1]. |
| Name | 2-hydroxy-3-phenylnaphthalene-1,4-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent[1]. |
|---|---|
| Related Catalog | |
| Target |
mitochondrial electron transport[1] |
| In Vitro | Antimalarial agent 14 (Compound N3) (0-400 μM, 48 h) inhibits P. falciparum with limited cytotoxicity against human cells[1]. Antimalarial agent 14 inhibits P. falciparum mitochondrial membrane potential with an IC50ΔΨmit of 16 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: P. falciparum and HEK293T Concentration: 0.128, 0.64, 3.2, 16, 80 and 400 μM Incubation Time: 48 h Result: Showed inhibition with an IC50 of 443 nM against P. falciparum and showed cytotoxicity with a CC50 of 54.6 ± 0.23 μM. |
| References |
| Density | 1.392g/cm3 |
|---|---|
| Boiling Point | 445.3ºC at 760 mmHg |
| Molecular Formula | C16H10O3 |
| Molecular Weight | 250.24900 |
| Flash Point | 237.2ºC |
| Exact Mass | 250.06300 |
| PSA | 54.37000 |
| LogP | 3.03490 |
| Vapour Pressure | 1.04E-08mmHg at 25°C |
| Index of Refraction | 1.693 |
| Storage condition | -20℃ |
| Precursor 9 | |
|---|---|
| DownStream 6 | |
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