Pedunculagin

Modify Date: 2024-01-08 18:37:44

Pedunculagin structure	Common Name	Pedunculagin
	CAS Number	113866-64-1	Molecular Weight	784.54100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₂₄O₂₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pedunculagin

Pedunculagin is a potent 5α-reductase type 1 inhibitor. Pedunculagin inhibits nitric oxide (NO), IL-6, IL-8 production. Pedunculagin decreases the protein expression of 5α-reductase. Pedunculagin shows anti-inflammatory activity[1].

Name	Pedunculagin
Synonym	More Synonyms

Description	Pedunculagin is a potent 5α-reductase type 1 inhibitor. Pedunculagin inhibits nitric oxide (NO), IL-6, IL-8 production. Pedunculagin decreases the protein expression of 5α-reductase. Pedunculagin shows anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5 alpha Reductase Research Areas >> Inflammation/Immunology
In Vitro	Pedunculagin 在 RAW 246.7 细胞中抑制一氧化氮 (NO) 的产生，IC50 值为 53.52 µM[1]。 Pedunculagin 在 HaCaT 细胞中抑制 IL-6、IL-8 的产生，IC50 分别为 6.59、0.09 µM[1]。 Pedunculagin (25, 50, 100 µM; 24 h) 降低 HaCaT 细胞中 5α-还原酶的蛋白表达[1]。 Western Blot Analysis[1] Cell Line: HaCaT cells Concentration: 25, 50, 100 µM Incubation Time: 24 h Result: Decreased the 5α-reductase protein expression in a dose-dependent manner.
References	[1]. Kim M, et al. Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition. Molecules. 2020 May 5;25(9):2154.