113866-64-1
113866-64-1 structure
- Name: Pedunculagin
- Chemical Name: Pedunculagin
- CAS Number: 113866-64-1
- Molecular Formula: C34H24O22
- Molecular Weight: 784.54100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5 alpha Reductase
- Create Date: 2017-09-18 10:25:28
- Modify Date: 2024-01-08 18:37:44
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Pedunculagin is a potent 5α-reductase type 1 inhibitor. Pedunculagin inhibits nitric oxide (NO), IL-6, IL-8 production. Pedunculagin decreases the protein expression of 5α-reductase. Pedunculagin shows anti-inflammatory activity[1].
| Name | Pedunculagin |
|---|---|
| Synonyms |
2,3,4,6-bis-(S)-HHDP-D-glucose
.pedunculagin |
| Description | Pedunculagin is a potent 5α-reductase type 1 inhibitor. Pedunculagin inhibits nitric oxide (NO), IL-6, IL-8 production. Pedunculagin decreases the protein expression of 5α-reductase. Pedunculagin shows anti-inflammatory activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Pedunculagin 在 RAW 246.7 细胞 中抑制一氧化氮 (NO) 的产生，IC50 值为 53.52 µM[1]。 Pedunculagin 在 HaCaT 细胞中抑制 IL-6、IL-8 的产生，IC50 分别为 6.59、0.09 µM[1]。 Pedunculagin (25, 50, 100 µM; 24 h) 降低 HaCaT 细胞中 5α-还原酶的蛋白表达[1]。 Western Blot Analysis[1] Cell Line: HaCaT cells Concentration: 25, 50, 100 µM Incubation Time: 24 h Result: Decreased the 5α-reductase protein expression in a dose-dependent manner. |
| References |
| Molecular Formula | C34H24O22 |
|---|---|
| Molecular Weight | 784.54100 |
| Exact Mass | 784.07600 |
| PSA | 377.42000 |
| LogP | 0.66540 |
| Precursor 0 | |
|---|---|
| DownStream 4 | |
![2,3-di-O-[(S)-4,5,6,4',5',6'-hexahydroxybiphenyl-2,2'-diyldicarbonyl]-(α/β)-D-glucopyranose structure](https://www.chemsrc.com/caspic/056/83541-38-2.png)
![2,3-di-O-[(S)-4,5,6,4',5',6'-hexahydroxybiphenyl-2,2'-diyldicarbonyl]-(α/β)-D-glucopyranose structure](https://www.chemsrc.com/caspic/094/83541-37-1.png)