Tenatoprazole

Modify Date: 2025-08-21 06:39:36

Tenatoprazole structure	Common Name	Tenatoprazole
	CAS Number	113712-98-4	Molecular Weight	346.40
	Density	1.4±0.1 g/cm3	Boiling Point	591.5±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₈N₄O₃S	Melting Point	178-180°C
	MSDS	Chinese USA	Flash Point	311.5±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of Tenatoprazole

Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV[1][2][3].

Name	Tenatoprazole
Synonym	More Synonyms

Description	Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV[1][2][3].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
In Vitro	Tenatoprazole (TU-199) (0.1, 0.2, 0.4 mg/kg; oral; single; Heidenhain-pouch dogs) dose-dependently suppresses gastric acid secretion stimulated by histamine infusion[4].
References	[1]. Thomson AB, et al. Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three-way crossover study. Aliment Pharmacol Ther. 2006;23(8):1179-1187. [2]. Uchiyama K, et al. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats. Methods Find Exp Clin Pharmacol. 1999;21(2):115-122. [3]. Mannemuddhu SS, et al. Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency. J Virol. 2021;95(13):e0246620. [4]. Uchiyama K, et al. The long-lasting effect of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion in dogs. J Pharm Pharmacol. 1999;51(4):457-464.

Density	1.4±0.1 g/cm3
Boiling Point	591.5±60.0 °C at 760 mmHg
Melting Point	178-180°C
Molecular Formula	C₁₆H₁₈N₄O₃S
Molecular Weight	346.40
Flash Point	311.5±32.9 °C
Exact Mass	346.109955
PSA	109.20000
LogP	1.36
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.674
Storage condition	−20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport

5-Methoxy-2-(4-...

CAS#:113713-24-9

~71%

Tenatoprazole

CAS#:113712-98-4

Literature: Sripathi, Somaiah; Bojja, Ramachandra Reddy; Karnati, Venugopal Reddy; Prasada Raju; Khunt, Mayur D. Organic Process Research and Development, 2009 , vol. 13, # 4 p. 804 - 806

Precursor 1
CAS#:113713-24-9 5-Methoxy-2-(4-...
DownStream 0

5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine

(±)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine

1H-Imidazo[4,5-b]pyridine, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-

5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-3H-imidazo[4,5-b]pyridine

tenatoprazole/tu-199

5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridin

Tenatoprazole

5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine

tenatoprazole monosodium

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China
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: TU-199
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tenatoprazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Tenatoprazole
Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/50mg
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

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Tenatoprazole

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